abstract：:The positive correlation between the number of M2 phenotype TAMs (M2‑TAMs) and tumour development suggests a supportive role of M2‑TAMs in glioma progression. In the present study, the molecular link between glioma cells and M2‑TAMs was investigated and it was demonstrated that transforming growth factor‑β1 (TGF‑β1) s...

journal_title：International journal of molecular medicine

authors： Liu Z,Kuang W,Zhou Q,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:Astrocyte activation has been described as a multi‑stage defensive response, which is characterized by the morphological alteration of astrocytes and the overexpression of intermediate filament proteins. However, the functional mechanism of the secretion system in activated astroglia remains unclear. It has previously...

journal_title：International journal of molecular medicine

authors： Zhan X,Li F,Chu Q,Pang H

更新日期：2018-12-01 00:00:00

abstract：:Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study i...

journal_title：International journal of molecular medicine

authors： Pei W,Zou Y,Wang W,Wei L,Zhao Y,Li L

更新日期：2018-12-01 00:00:00

abstract：:Hyperosmotic stress may be initiated during a diverse range pathological circumstances, which in turn results in tissue damage. In this process, the activation of survival signaling, which has the capacity to restore cell homeostasis, determines cell fate. Autophagy is responsible for cell survival and is activated by...

journal_title：International journal of molecular medicine

authors： Zhu H,Cao W,Zhao P,Wang J,Qian Y,Li Y

更新日期：2018-12-01 00:00:00

abstract：:Non‑small cell lung carcinoma (NSCLC) is a life‑threatening malignancy. The level of the cell growth regulator mitogen‑activated protein kinase kinase kinase kinase 3 (MAP4K3) has been shown to be correlated with a high risk of NSCLC recurrence and poor recurrence‑free survival rate. The present study examined the eff...

journal_title：International journal of molecular medicine

authors： Zhou Y,Hong T,Tong L,Liu W,Yang X,Luo J,Wang F,Li J,Yan L

更新日期：2018-12-01 00:00:00

abstract：:Curcumin is an orange-yellow colored, lipophilic polyphenol substance derived from the rhizome of Curcuma longa that is widely used in many countries. Curcumin has many reported functions, including antioxidant and anti‑inflammatory effects. Autophagy removes damaged organelles and protein aggregates in the cell. Howe...

journal_title：International journal of molecular medicine

authors： Wang JL,Wang JJ,Cai ZN,Xu CJ

更新日期：2018-11-01 00:00:00

abstract：:The increased expression of sialyl-Lewisx (SLex) epitope on the surface of tumor cells has been known for decades. However, genetic manipulation of the expression of SLex and the role of SLex in cancer cell proliferation remains to be fully elucidated. The present study suggested that the monoclonal antibody of SLex (...

journal_title：International journal of molecular medicine

authors： Li D,Sun H,Bai G,Wang W,Liu M,Bao Z,Li J,Liu H

更新日期：2018-11-01 00:00:00

abstract：:The aim of the current study was to explore the potential of TREK‑TRAAK two‑pore domain potassium (K2P) channels in protecting human retinal pigment epithelium (hRPE) cells against oxidative stress. hRPE cells were obtained from donors, and then cell identification and detection of the expression levels of TREK‑TRAAK ...

journal_title：International journal of molecular medicine

authors： Huang H,Li H,Shi K,Wang L,Zhang X,Zhu X

更新日期：2018-11-01 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is associated with psychological stress. However, the full landscape of IBS‑related epigenetic factors remains unveiled and needs to be elucidated. The water‑avoidance stress (WAS) method was used to induce a rat IBS model. Each rat was monitore...

journal_title：International journal of molecular medicine

authors： Zhu S,Min L,Guo Q,Li H,Yu Y,Zong Y,Wang L,Li P,Gu J,Zhang S

更新日期：2018-11-01 00:00:00

abstract：:A previous study has revealed that oxidized low‑density lipoprotein (oxLDL)/β2‑glycoprotein I (β2GPI)/anti‑β2‑glycoprotein I (anti‑β2GPI), an immune complex, is able to activate the Toll‑like receptor 4 (TLR4)/nuclear factor κβ (NF‑κβ) inflammatory signaling pathway in macrophages, and consequently enhance foam cell f...

journal_title：International journal of molecular medicine

authors： Wang T,Ouyang H,Zhou H,Xia L,Wang X,Wang T

更新日期：2018-10-01 00:00:00

abstract：:Mitogen‑activated protein kinase‑activated protein kinase 2 (MK2) and its mediated inflammation are involved in various diseases, including spinal cord injury (SCI). Ultrashortwave (USW) radiation has previously been reported to exert a protective effect on SCI. In the present study, through a series of reverse transc...

journal_title：International journal of molecular medicine

authors： Wang N,Feng Z,Zhao W,Zhang Z,Zhang L

更新日期：2018-10-01 00:00:00

abstract：:Inducible heat shock protein 70 (HSP70; also known as HSPA1 or HSP72) is implicated in cancer. As a stress‑inducible heat shock protein, HSP70 is highly expressed in a variety of cancers and correlates with metastasis, chemotherapy resistance and tumor prognosis. The present study demonstrated that suppression of HSP7...

journal_title：International journal of molecular medicine

authors： Sheng L,Tang T,Liu Y,Ma Y,Wang Z,Tao H,Zhang Y,Qi Z

更新日期：2018-10-01 00:00:00

abstract：:In the present study, high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was applied to live Pseudomonas aeruginosa (PA) bacterial cells to determine the metabolome of this opportunistic Gram-negative human pathogen, and in particular, its response to the volatile aromatic low m...

journal_title：International journal of molecular medicine

authors： Righi V,Constantinou C,Kesarwani M,Rahme LG,Tzika AA

更新日期：2018-10-01 00:00:00

abstract：:Cervical cancer is one of the most common types of female malignant tumor. It is well established that radiotherapy (RT) is the first‑line treatment of cervical cancer; however, radioresistance is a substantial obstacle to cervical cancer RT. At present, the mechanism underlying radioresistance remains unclear. Emergi...

journal_title：International journal of molecular medicine

authors： Fan L,Huang C,Li J,Gao T,Lin Z,Yao T

更新日期：2018-10-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a lack of potential biomarkers for the diagnosis and treatment of patients with PH...

journal_title：International journal of molecular medicine

authors： Wang J,Zhu MC,Kalionis B,Wu JZ,Wang LL,Ge HY,Chen CC,Tang XD,Song YL,He H,Xia SJ

更新日期：2018-09-01 00:00:00

abstract：:Tongue squamous cell carcinoma (TSCC) is highly malignant and poorly differentiated, resulting in a high frequency of local recurrence and distant metastases. Sox2 (Sry‑box2), an important factor in embryonic development and cell differentiation, has been shown to associate with malignant phenotypes and epithelial‑mes...

journal_title：International journal of molecular medicine

authors： Liu X,Qiao B,Zhao T,Hu F,Lam AK,Tao Q

更新日期：2018-09-01 00:00:00

abstract：:Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons. Nerve growth fact...

journal_title：International journal of molecular medicine

authors： Ohta M,Chosa N,Kyakumoto S,Yokota S,Okubo N,Nemoto A,Kamo M,Joh S,Satoh K,Ishisaki A

更新日期：2018-09-01 00:00:00

abstract：:Ketamine (KTM) is an anesthetic drug with several advantages, including the elevation of cardiac output and blood pressure. However, KTM may also induce the apoptosis of hippocampal neurons. Notably, p38 mitogen‑activated protein kinase (p38MAPK) has previously been studied for its role in neuronal injury. Therefore, ...

journal_title：International journal of molecular medicine

authors： Guo XQ,Cao YL,Zhao L,Zhang X,Yan ZR,Chen WM

更新日期：2018-09-01 00:00:00

abstract：:Effective drugs and strategies for treating type 2 diabetes mellitus (2‑DM) are urgently required. The aim of the present study was to elucidate the mechanism underlying microRNA (miR)‑6835‑3p regulation of adiponectin receptor 1 (AdipoR1) expression and the miR‑6835‑3p/AdipoR1 signaling pathway in pancreatic islet ce...

journal_title：International journal of molecular medicine

authors： Wang H,Jiang L,Li Z,Wang W,Hao C

更新日期：2018-09-01 00:00:00

abstract：:MicroRNA‑23b‑3p (miR‑23b‑3p) has been reported to be involved in the pathogenesis of a number of diseases, including non‑small cell lung cancer and gastric cancer, by acting on different signaling pathways. The present study aimed to understand the association between the miR‑23b‑3p level of intracranial aneurysms (IA...

journal_title：International journal of molecular medicine

authors： Guo D,Wang YW,Yan L,Ma J,Han XW,Shui SF

更新日期：2018-09-01 00:00:00

abstract：:Subsequently to the publication of this article, the authors have realized that the address affiliation for the corresponding author, Chengheng Hu, and the authors Longyun Peng and Xinxue Liao appeared incorrectly. These authors' affiliation information should have appeared as follows (the corrected address affiliatio...

journal_title：International journal of molecular medicine

authors： Ke X,Chen J,Peng L,Zhang W,Yang Y,Liao X,Mo L,Guo R,Feng J,Hu C,Nie R

更新日期：2018-09-01 00:00:00

abstract：:In the above paper, the authors realize that an error inadvertently appeared in the funding section on p. 895. Where "This study was supported by the National Natural Science Foundation of China Science Fund Project (grant no. 30960389 and 8176010097)" was written, the application number 8176010097 was featured incorr...

journal_title：International journal of molecular medicine

authors： Li G,Zhou R,Zhao X,Liu R,Ye C

更新日期：2018-08-27 00:00:00

abstract：:β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulator...

journal_title：International journal of molecular medicine

authors： Katoh M

更新日期：2018-08-01 00:00:00

abstract：:The ectromelia virus (ECTV) is a mouse specific Orthopoxvirus that causes lethal infection in some mouse strains. ECTV infection of these mouse strains has been used as a valuable model for understanding the interplay between Orthopoxvirus species and their hosts, including variola virus in humans. Although poxviruses...

journal_title：International journal of molecular medicine

authors： Cheng W,Jia H,Wang X,He X,Jin Q,Cao J,Jing Z

更新日期：2018-08-01 00:00:00

abstract：:Myocardial ischemic injury results from severe impairment of the coronary blood supply and may lead to metabolic and ultrastructural changes, thereby causing irreversible damage. MicroRNA (miR)‑20b‑5p has been demonstrated to be involved in malignancies of the breast, colorectum, stomach, blood and oropharynx. The pre...

journal_title：International journal of molecular medicine

authors： Liang ZG,Yao H,Xie RS,Gong CL,Tian Y

更新日期：2018-08-01 00:00:00

abstract：:Thioredoxin domain‑containing 5 (TXNDC5) is reportedly overexpressed in colorectal cancer (CRC) and is therefore considered an oncogene. However, the role of TXNDC5 in CRC tumorigenesis remains unclear. The present study aimed to explore the role of TXNDC5 in CRC tumorigenesis in vitro and in vivo under hypoxic and no...

journal_title：International journal of molecular medicine

authors： Tan F,Zhu H,He X,Yu N,Zhang X,Xu H,Pei H

更新日期：2018-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM represents >50% of primary tumors of the nervous system and ~20% of intracranial neoplasms. Standard treatment involves surgery, radiation and chemotherapy. However, the prognosis of GBM is usually poor, with a median survival of 15 months. ...

journal_title：International journal of molecular medicine

authors： Bryukhovetskiy I,Ponomarenko A,Lyakhova I,Zaitsev S,Zayats Y,Korneyko M,Eliseikina M,Mischenko P,Shevchenko V,Shanker Sharma H,Sharma A,Khotimchenko Y

更新日期：2018-08-01 00:00:00

abstract：:Inflammatory genes serve a crucial role in the pathogenesis of inflammation‑associated tumors. However, as recent studies have mainly focused on the effects of single inflammatory genes on colorectal cancer (CRC), but not on the global interactions between genes, the underlying mechanisms between inflammatory genes and...

journal_title：International journal of molecular medicine

authors： Jiang H,Dong L,Gong F,Gu Y,Zhang H,Fan D,Sun Z

更新日期：2018-07-01 00:00:00

abstract：:Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the...

journal_title：International journal of molecular medicine

authors： Ozcagli E,Kara M,Kotil T,Fragkiadaki P,Tzatzarakis MN,Tsitsimpikou C,Stivaktakis PD,Tsoukalas D,Spandidos DA,Tsatsakis AM,Alpertunga B

更新日期：2018-07-01 00:00:00

abstract：:Despite the improvement in gastric cancer (GC) treatment, multidrug resistance (MDR) is still a significant reason for chemotherapy failure. Our previous studies have demonstrated that miR-19a/b upregulation directly promoted MDR in GC cells. However, the exact regulation and the potential molecule mechanisms have not...

journal_title：International journal of molecular medicine

authors： Zhu F,Wu Q,Ni Z,Lei C,Li T,Shi Y

更新日期：2018-07-01 00:00:00

abstract：:The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague‑Dawley rats. Chondrocytes were treated with various concentrations of GlcN or without GlcN. The effects of GlcN on chondrocyte proliferation were de...

journal_title：International journal of molecular medicine

authors： Ma Y,Zheng W,Chen H,Shao X,Lin P,Liu X,Li X,Ye H

更新日期：2018-07-01 00:00:00

abstract：:The present study aimed to investigate the diagnostic and prognostic values of contrast‑enhanced ultrasound (CEUS) combined with diffusion‑weighted magnetic resonance imaging (DW‑MRI) in different subtypes of breast cancer (BC). CEUS and DW‑MRI were conducted in 232 patients with BC prior to surgical treatment. Patien...

journal_title：International journal of molecular medicine

authors： Liu GF,Wang ZQ,Zhang SH,Li XF,Liu L,Miao YY,Yu SN

更新日期：2018-07-01 00:00:00

abstract：:Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a cruc...

journal_title：International journal of molecular medicine

authors： Ding Q,Sun P,Zhou H,Wan B,Yin J,Huang Y,Li Q,Yin G,Fan J

更新日期：2018-07-01 00:00:00

abstract：:Poligoni Multiflori Radix (PMR) is a traditional Korean medicinal herb that is known to have various pharmacological effects, including antihyperlipidemic, anticancer, and anti‑inflammatory effects. However, the effects of PMR on bone metabolism have not been elucidated to date. The present study aimed to investigate ...

journal_title：International journal of molecular medicine

authors： Han SY,Lee KH,Kim YK

更新日期：2018-07-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress plays a vital role in mediating ischemic reperfusion damage in brain. In this study, we evaluated whether melatonin inhibits ER stress in cultured neurons exposed to oxygen and glucose deprivation (OGD) and in rats subjected to transient focal cerebral ischemia. Sprague-Dawley rats we...

journal_title：International journal of molecular medicine

authors： Lin YW,Chen TY,Hung CY,Tai SH,Huang SY,Chang CC,Hung HY,Lee EJ

更新日期：2018-07-01 00:00:00

abstract：:Adipose tissue tumors (lipomas) frequently develop in patients with heterozygous germ line phosphatase and tensin homolog (PTEN) mutations. simvastatin has been demonstrated to exhibit antitumor effects, and so the aim of the present study was to assess the effects of simvastatin on the growth of human PTEN haploinsuf...

journal_title：International journal of molecular medicine

authors： Kässner F,Sauer T,Penke M,Richter S,Landgraf K,Körner A,Kiess W,Händel N,Garten A

更新日期：2018-06-01 00:00:00

abstract：:In contrast to healthy intervertebral discs (IVDs), degenerate IVDs become vascularized. Here, we determined the role of an angiogenesis promoter, angiopoietin (Ang)-2, in the pathology of IVD degeneration (IDD). We evaluated degree of IDD using the Pfirrmann grading system. We used quantitative real-time polymerase c...

journal_title：International journal of molecular medicine

authors： Wang K,Kang L,Liu W,Song Y,Wu X,Zhang Y,Hua W,Zhao K,Li S,Tu J,Luo R,Yang C

更新日期：2018-06-01 00:00:00

abstract：:The transcription factor nuclear factor-κB (NF-κB) has been shown to function as a key regulator of cell death or survival in neuronal cells. Previous studies indicate that the biphasic activation of NF-κB occurs following experimental neonatal hypoxia-ischemia and subarachnoid hemorrhage. However, the comprehensive u...

journal_title：International journal of molecular medicine

authors： Zhang H,Zhang D,Li H,Yan H,Zhang Z,Zhou C,Chen Q,Ye Z,Hang C

更新日期：2018-06-01 00:00:00

abstract：:Ovarian cancer is the main cause of gynecological cancer‑associated mortality around the world. Despite initial responses to chemotherapy, frequent relapse occurs. Daidzein is an important flavonoid and has been shown to exhibit a diversity of pharmacological properties, including antimicrobial and anticancer activiti...

journal_title：International journal of molecular medicine

authors： Hua F,Li CH,Chen XG,Liu XP

更新日期：2018-06-01 00:00:00

abstract：:The most common tumors in children are infantile hemangiomas which could cause morbidity and severe complications. The development of novel alternative drugs to treat infantile hemangiomas is necessary, since Hemangeol is the only US Food and Drug Administration-approved drug for infantile hemangiomas. However, Hemang...

journal_title：International journal of molecular medicine

authors： Li H,Teng Y,Xu X,Liu J

更新日期：2018-06-01 00:00:00